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FIGURE 5 Changes in RAAS and natriuretic modulators after 1 week and 12 weeks of treatment. Changes in (a) urine adenosine, (b) plasma NT-proANP, (c) plasma <t>angiotensinogen,</t> (d) plasma angiotensin-converting enzyme (ACE), and (e) ACE-2 activity during Week 1 and Week 12 of ertugliflozin treatment or placebo subtracted from baseline values.
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FIGURE 5 Changes in RAAS and natriuretic modulators after 1 week and 12 weeks of treatment. Changes in (a) urine adenosine, (b) plasma NT-proANP, (c) plasma <t>angiotensinogen,</t> (d) plasma angiotensin-converting enzyme (ACE), and (e) ACE-2 activity during Week 1 and Week 12 of ertugliflozin treatment or placebo subtracted from baseline values.
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FIGURE 5 Changes in RAAS and natriuretic modulators after 1 week and 12 weeks of treatment. Changes in (a) urine adenosine, (b) plasma NT-proANP, (c) plasma <t>angiotensinogen,</t> (d) plasma angiotensin-converting enzyme (ACE), and (e) ACE-2 activity during Week 1 and Week 12 of ertugliflozin treatment or placebo subtracted from baseline values.
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FIGURE 5 Changes in RAAS and natriuretic modulators after 1 week and 12 weeks of treatment. Changes in (a) urine adenosine, (b) plasma NT-proANP, (c) plasma <t>angiotensinogen,</t> (d) plasma angiotensin-converting enzyme (ACE), and (e) ACE-2 activity during Week 1 and Week 12 of ertugliflozin treatment or placebo subtracted from baseline values.
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Genechem lentivirus carrying shrna-#3 against the human lamc1 target sequence 5’-caa agt tct caa gtc cta t-3
FIGURE 5 Changes in RAAS and natriuretic modulators after 1 week and 12 weeks of treatment. Changes in (a) urine adenosine, (b) plasma NT-proANP, (c) plasma <t>angiotensinogen,</t> (d) plasma angiotensin-converting enzyme (ACE), and (e) ACE-2 activity during Week 1 and Week 12 of ertugliflozin treatment or placebo subtracted from baseline values.
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FIGURE 5 Changes in RAAS and natriuretic modulators after 1 week and 12 weeks of treatment. Changes in (a) urine adenosine, (b) plasma NT-proANP, (c) plasma angiotensinogen, (d) plasma angiotensin-converting enzyme (ACE), and (e) ACE-2 activity during Week 1 and Week 12 of ertugliflozin treatment or placebo subtracted from baseline values.

Journal: Physiological reports

Article Title: Mechanistic evaluation of ertugliflozin in patients with type 2 diabetes and heart failure.

doi: 10.14814/phy2.70275

Figure Lengend Snippet: FIGURE 5 Changes in RAAS and natriuretic modulators after 1 week and 12 weeks of treatment. Changes in (a) urine adenosine, (b) plasma NT-proANP, (c) plasma angiotensinogen, (d) plasma angiotensin-converting enzyme (ACE), and (e) ACE-2 activity during Week 1 and Week 12 of ertugliflozin treatment or placebo subtracted from baseline values.

Article Snippet: Aldosterone, catecholamines, and urine adenosine were measured using chromatography and mass spectrometry, while ELISA was used to measure urine cGMP (Catalog No. MBS160025), 8- isoprostane (Catalog No. ab175819), NO (Catalog No. KGE001), angiotensin II (Catalog No. MBS703599), and angiotensinogen (Catalog No. DY3156- 05) levels (R&D Systems, Minneapolis, MN).

Techniques: Clinical Proteomics, Activity Assay